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The downregulation was 0.29-fold, 0.22-fold, and 0.16-fold, respectively, compared to the control group ( P 0.05)

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In VaD, an insufficient oxygen supply to the brain, reduced blood flow, and decreased intracellular oxygen partial pressure result in mitochondrial oxidative phosphorylation dysfunction, inhibition of protein synthesis, insufficient ATP production, and energy depletion, ultimately leading to sodium-potassium pump failure, calcium overloading, and disturbances in cytosolic ions (e.g., Ca 2+ , Na + , H + , ROS), which subsequently increase

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Parkinsons disease is associated with impaired gut-blood barrier for short-chain fatty acids